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KMID : 1161420150180091013
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Journal of Medicinal Food
2015 Volume.18 No. 9 p.1013 ~ p.1021
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Solanum tuberosum L. cv Jayoung Epidermis Extract Inhibits Mite Antigen-Induced Atopic Dermatitis in NC/Nga Mice by Regulating the Th1/Th2 Balance and Expression of Filaggrin
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Yang Gab-Sik
Cheon Se-Yun
Chung Kyung-Sook
Lee Sung-Jin
Hong Chul-Hee
Lee Kyung-Tae
Jang Dae-Sik
Jeong Jin-Cheol
Kwon Oh-Keun
Nam Jung-Hwan
An Hyo-Jin
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Abstract
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Solanum tuberosum L. cv Jayoung (JY) is a potato with dark purple flesh and contains substantial amounts of polyphenols. In this study, we evaluated the therapeutic effects of S. tuberosum L. cv JY in a mouse model of Dermatophagoides farinae body (Dfb)-induced atopic dermatitis (AD). The ethanol extract of the peel of JY (EPJ) ameliorated Dfb-induced dermatitis severity, serum levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine. Histological analysis of the skin also revealed that EPJ treatment significantly decreased mast cell infiltration. The suppression of dermatitis by EPJ treatment was accompanied by a decrease in the skin levels of type 2 helper T-cell cytokines such as interleukin (IL)-4, IL-5, and IL-13. The induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also decreased in the skin by EPJ. Nuclear translocation of nuclear factor-κB p65 was decreased by EPJ in Dfb-induced NC/Nga mice. The protein expression of filaggrin in the AD-like skin lesions was restored by EPJ treatment. These results suggested that EPJ may be a potential therapeutic tool for the treatment of AD.
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KEYWORD
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atopic dermatitis, IgE, NF-κB, Solanum tuberosum L. cv Jayoung, Th2
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